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Could egg defect breakthrough help stop the ‘horrible IVF rollercoaster’?

1 day ago
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It is a rollercoaster of emotional extremes that will be familiar to many who have gone through IVF treatment: hope and joy turns to despair and back again.This is especially true for women over 35, the age when IVF success rates decline steeply and for whom the only real way to improve the odds is to keep trying.While there has been huge progress in IVF in the past decades, including the advent of genetic testing, egg freezing and techniques to overcome male infertility, the primary cause of age-related female infertility – egg quality – has not been directly addressed.Now, groundbreaking research presented at the Fertility 2026 in Edinburgh this week, suggests progress is on the horizon.Scientists from a leading lab in Germany say they have been able to reverse a common age-related defect in eggs in an advance that they predict could be transformative.

“Currently there are no methods for improving the ageing egg,It is a very large unmet need,” said Dr Agata Zielinska, co-CEO of Ovo Labs, and one of the scientists behind the advance,“This would be a first-in-class solution for improving egg quality,”Eggs are uniquely vulnerable to ageing as women are born with all their eggs,Sperm, by contrast, is continuously generated from stem cells in the testes throughout adult life.

In IVF treatment, women under 35 had an average birth rate for each embryo transferred of 35% compared with just 5% for women aged 43-44, according to the most recent figures from UK clinics.And it is the age of the egg, not the woman, that matters most.When older women use younger donor eggs or their own frozen eggs the success rate is almost entirely defined by the age of the egg.“Female eggs sit there for a really long time,” said Dr Güneş Taylor, who researches female fertility at the University of Edinburgh.“It’s been quite hard to get a grip on what is going wrong with them.

They’re meant to be dormant.”A key part of this puzzle appears to have been cracked by scientists working in the lab of Prof Melina Schuh, a director at the Max Planck Institute for Multidisciplinary Sciences in Göttingen and co-founder of Ovo Labs.They found that as eggs age they have less of a crucial protein, called Shugoshin 1, which acts as a glue to keep the egg’s chromosomes neatly stuck together in X-shaped pairs.Without enough of this adhesive, the chromosomes start to fray apart.This means the chromosome pairs won’t split evenly when the egg is fertilised, leading to a higher rate of embryos with the wrong number of chromosomes.

Often, these embryos will begin developing normally, but are not ultimately viable.For IVF patients, this can create an initial sense of hope that is destined to turn to disappointment.“What’s weird about humans is that in the absence of the normal number of chromosomes you can still get quite a long way,” said Taylor.“That’s how you end up with this horrible IVF rollercoaster when you seem to get pregnant and then the cycle fails.”The latest work provides tantalising evidence that an important age-related defect in eggs could be reversible.

In results presented in Edinburgh, they showed that eggs that were supplemented with Shugoshin 1 were almost half as likely to show the chromosome defect.This suggests that there could be a window of opportunity in IVF treatment between harvesting the eggs and fertilising them in which eggs could be given a rejuvenating microinjection.“Our aim is to really reduce the time to successful conception,” said Zielinska.“Many more women would be able to conceive within a single IVF attempt.”The research is still at an experimental stage and will need years of further testing.

And, in a field known for over-hyping expensive IVF add-ons, patients are right to reserve judgment.Ovo Labs still needs to prove that its proposed technique is safe and that the apparent improvements in egg quality translate to a real difference in IVF rates.The team did not wish to put a time-frame on how long this might take when asked whether this could be a couple of years, five years or a decade.“We don’t want to overpromise,” said Schuh.There is hope, though, that the advance could be a step to overcoming one of the major causes of female infertility – and the reason why the IVF journey is so often so painful.

“While we await further details and confirmatory clinical trials, including addressing safety issues, these results have great potential for improving IVF success rates,” said Prof Richard Anderson, head of obstetrics and gynaecology at the University of Edinburgh, who was not involved in the work.“We all have friends who have been struggling with IVF,” said Schuh.“It’s a long journey and such an emotional burden.I really hope we can make this entire experience more successful.”
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US economy added fewer jobs than forecast in December, but January interest rate cut very unlikely – as it happened

Newsflash: The US economy added fewer jobs than expected last month.America’s non-farm payroll rose by 50,000 in December, missing forecasts of a 60,000 rise.Employment continued to trend up in food services and drinking places, health care, and social assistance, the Bureau of Labor Statistics reports, while retail trade lost jobs.That shows a hiring slowdown, compared with the previous month; the BLS now estimates that 56,000 jobs were created in November, 8,000 fewer than its first estimate of 64,000.Time to wrap up!Hiring held firm in the US last month, official data showed, amid uncertainty over the strength and direction of the world’s largest economy

1 day ago
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High costs, falling returns: what could go wrong for Trump’s Venezuela oil gamble?

Donald Trump has laid claim to billions of dollars’ worth of Venezuelan crude this week, which at a stroke has handed the world’s biggest consumer of oil up to 50m barrels – but his ambitions are far greater.The White House said Venezuela would be “turning over” the nearly $3bn (£2.3bn) of crude stranded in tankers and storage facilities before it is sold on the international market and after that the US plans to control all the country’s oil sales “indefinitely”.For the Trump administration, the seizure is the first move in taking control of Venezuela’s vast crude reserves, estimated to represent almost a fifth of the proven reserves on Earth, in a push to cut the oil price to $50 a barrel.But experts have been quick to point out that the crude cargo grab could be the last easy win for the president, with no quick or cheap fix to reignite the country’s oil production

1 day ago
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Charity watchdog opens inquiry into City & Guilds’ sale of business arm

The Charity Commission has opened a statutory inquiry into City & Guilds’ sale of its qualification awards business to a private company last year.The announcement has been made after the Guardian revealed last month how City & Guilds bosses were handed million-pound bonuses after the charity privatised its business arm.The payments – which are understood to include a £1.7m award for the chief executive, Kirstie Donnelly, and £1.2m to the finance director, Abid Ismail – emerged after reports of how the privatised City & Guilds business has also embarked on a £22m cost-cutting drive and is shrinking its UK workforce after being sold by its charity owner to PeopleCert, an international certification company

1 day ago
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Starmer rules out EU financial services alignment talks

Keir Starmer will exclude financial services from negotiations on closer alignment with the EU, prompting a sigh of relief from Brexit-weary City lobbyists.A government spokesperson said officials would continue to explore cooperation “where it is in our economy’s interest”, but it is understood there will be no push for City firms to return to the Brussels rulebook.The exclusion, first reported by the Financial Times, comes despite City bosses having largely backed EU membership in the run-up to the 2016 referendum and later warning of widespread disruption and job losses moving to the continent. Today, however, few are keen to face another period of uncertainty and potential unwinding of post-Brexit changes.UK regulators have been under pressure to dismantle a series of EU-era rules that politicians argue have hampered competitiveness and growth

1 day ago
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Sainsbury’s blames ‘significant headwinds’ for drop in Argos sales at Christmas

Sainsbury’s has blamed “significant headwinds” from weak consumer confidence, heavy online competition and widespread discounting for a fall in sales at its Argos chain over the all-important Christmas quarter.The UK’s second-largest grocer said its supermarkets increased sales by 3.4% at established stores in the three months to 3 January but Argos sales fell 1% in the period.Argos, which has more than 600 stores and 400 collection points, most of which are within Sainsbury’s outlets, performed particularly badly in the crucial final six weeks, with total sales down 2.2% compared with the Sainsbury’s chain’s 4

2 days ago
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Mining firms Rio Tinto and Glencore restart $260bn merger talks

Rio Tinto and Glencore have restarted talks over a merger that would create the world’s largest mining company.The talks come almost a year after previous discussions between the two mining companies collapsed. If a deal is agreed, it would create a global mining business with an enterprise value of more than $260bn (£193bn).The two companies said on Friday that they were in “preliminary discussions” about a “possible combination of some or all of their businesses, which could include an all-share merger”.Rio Tinto, which has an enterprise value of $162bn, said the deal under discussion would potentially result in it acquiring Glencore

2 days ago
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NFL wildcard weekend predictions: Allen can carry Bills – if he can handle the pressure

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Ashes 2025-26: our writers’ end-of-series England v Australia awards

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Free agent outfielder Max Kepler hit with 80-game ban for positive drug test

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France taps out as G7 summit moved to avoid clash with White House UFC event

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England ruthlessly privatised cricket – Australia embraces it with constant public displays of affection | Emma John

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Your Guardian sport weekend: FA Cup third round, NFL playoffs begin and the WSL returns

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