Lacunar strokes caused by widening of arteries in brain, study suggests
The cause of a type of stroke that affects about 35,000 people across the UK each year has been uncovered by researchers and may explain why some medications are ineffective as treatment.Lacunar strokes, which account for a quarter of all strokes in the UK, had been linked to the blockage of arteries in the brain by fatty deposits.However, a study published on Wednesday suggests they are not caused by blocked arteries but by the enlargement and widening of arteries in the brain.This would help to explain why aspirin and other blood thinners, commonly used to prevent ischaemic strokes, are not as effective in preventing lacunar stroke.The research by academics at the University of Edinburgh and the UK Dementia Research Institute analysed 229 patients who had experienced either a lacunar or mild non-lacunar stroke.
Maeva May, the director of policy for the Stroke Association, said the findings “illustrate the value of research and the potential it has to change the lives of stroke patients”.“There is still so much we don’t know about stroke despite it being the leading cause of complex adult disability and the fourth leading cause of death in the UK,” May said.“Answering these questions and developing effective treatments is crucial to help ensure a good recovery for the 240 people who survive stroke every day in the UK.“Stroke research is chronically underfunded, with less than 1% of total UK research funding spent on the condition.This study – and more of its kind – need to be a national priority across the NHS, government and the wider research community with clear pathways to carry breakthrough discoveries from laboratory to patients.
”More specifically, the study found that the narrowing of large arteries was instead more commonly seen in other types of stroke.Instead, widening arteries showed strong links to lacunar disease, with patients who experienced this being more than four times more likely to have a lacunar stroke.Joanna Wardlaw, a professor of applied neuroimaging at the University of Edinburgh and group leader at the UK Dementia Research Institute, said: “This study provides strong evidence that lacunar stroke is not caused by fatty blockage of larger arteries, but by disease of the small vessels within the brain itself.“Recognising this distinction is crucial, because it explains why conventional treatments like anti-platelet drugs are not as effective for this type of stroke and highlights the urgent need to develop new therapies that target the underlying microvascular damage.”
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From The Sheep Detectives to Rivals: your complete entertainment guide to the week ahead
Hugh Jackman and Emma Thompson star in a farmyard mystery, while the spirited bonkbuster returns for a smutty second outingThe Sheep DetectivesOut now Few can claim a writing career as varied as Craig Mazin, creator of TV’s Chernobyl, co-writer of several Scary Movie and The Hangover films, and co-creator of The Last of Us. Here, he turns his hand to a comedy-mystery about sheep, starring Hugh Jackman and Emma Thompson. Adapted from a novel by Leonie Swann.KokuhoOut now Two-time Japan Academy film prize best director winner Lee Sang-il directs this prestige adaptation of Shuichi Yoshida’s novel. It holds the record for the highest-grossing Japanese live-action release ever in Japan – an impressive feat for a nearly three-hour-long period drama set across five decades in the kabuki theatre world
Historic Oxford cinema under threat as Oriel College refuses to extend lease
The survival of one of the UK’s oldest independent cinemas is under threat while its landlord, the University of Oxford’s Oriel College, refuses to extend its lease to allow what its director says are vital renovations.The Ultimate Picture Palace in east Oxford opened in 1911, and has entertained generations of students and residents, including the Oscar-winning director Sam Mendes. It sells tickets for its 106 seats through an old-fashioned box office window to patrons queueing on the street, and its screen is behind a manually opened curtain.After decades of instability, the UPP, as it is known by locals, recently became a community-owned business when more than 1,200 supporters raised funds to keep the cinema operating in the Grade II-listed building.But plans to secure its long-term future have been dashed by Oriel College’s reluctance to approve an extension that would allow further investments and renovations to take place
Arthur Miller opens up about marriage to Marilyn Monroe in newly unearthed recordings
He was one of the greatest playwrights of the 20th century and she was one of the greatest actors. In newly unearthed recordings made over a period of nearly three decades, Arthur Miller opened up about his short-lived marriage to Marilyn Monroe, saying she wanted a husband who was a “father, lover, friend and agent,” and the child she longed for would have been an “additional problem”.In taped conversations with his friend and biographer Prof Christopher Bigsby, Miller said he had felt “death was always on her [Monroe’s] shoulder – always”. He had believed that if he did not “take care of her life” she would come to a “catastrophic end”.“One time I brought doctors to pump her out because she had swallowed enough stuff [drugs] to kill her,” he said
Man charged over bomb hoax after Peter Kay show evacuated
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Royal Opera House calls for release of Georgian bass singer jailed over democracy protests
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