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Most statin side-effects not caused by the drugs, study finds

2 days ago
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Almost all side-effects listed for statins are not caused by the drugs, according to the world’s most comprehensive review of evidence.Other than the well-known risks around muscle pain and diabetes, only four of 66 other statin side-effects listed on labels – liver test changes, minor liver abnormalities, urine changes and tissue swelling – are supported by evidence.And the risks are very small, according to the systematic review and meta-analysis published in the Lancet.Statins have been used by hundreds of millions of people worldwide over the last three decades and are proven to reduce heart attacks, strokes and cardiovascular deaths.At the same time, millions have been put off the drugs amid long-running safety concerns, with statin labels listing dozens of possible side-effects.

The study is the most comprehensive assessment of evidence for listed side-effects of statins.It examined 19 randomised controlled trials involving 124,000 people, with an average follow-up of four and a half years.Of the 66 side-effects currently listed on product labels, researchers found no strong evidence to support statins causing 62 of them, such as memory problems, depression, sleep disturbances and nerve damage leading to tingling in the hands and feet.The results showed the risk of most listed side-effects was minimal while the benefits far outweighed potential harms.As a result, labels should be updated to better reflect the evidence so patients and doctors could make more informed choices about statins, the researchers said.

The study’s lead author, Christina Reith, an associate professor at Oxford University, said: “What we were able to show reliably was that statins did not make these commonly experienced events occur more often.“So for example, the percentage of people suffering memory loss per year was similar to those taking statin therapy as those not, equally.The percentage of people suffering sleep problems per year was similar to those taking statin therapy as for those not.“This means that we now have really good evidence that although these things may well happen to people while they take statins, that statins are not the cause of these problems.”While the study also noted the potential for side-effects appearing after statin use for longer than the average follow-up time, Reith said it provided “reassurance that, for most people, the risk of side-effects is greatly outweighed by the benefits of statins”.

Prof Sir Rory Collins, emeritus professor of medicine and epidemiology at Oxford and a senior author of the paper, said: “Now that we know that statins do not cause the majority of side-effects listed in package leaflets, statin information requires rapid revision to help patients and doctors make better-informed health decisions,”Prof Bryan Williams, chief scientific and medical officer at the British Heart Foundation, which part-funded the research, said: “Statins are life-saving drugs, which have been proven to protect against heart attacks and strokes,This evidence is a much-needed counter to the misinformation around statins and should help prevent unnecessary deaths from cardiovascular disease,”Prof Victoria Tzortziou Brown, chair of the Royal College of GPs, said: “Those considering taking statins should be reassured by this comprehensive study, which shows that while statins, like any medication, have potential side-effects, the risk for most people is low,“It remains important to note that while statins can have real benefits for some patients, they won’t be appropriate for everyone so the decision to prescribe should always be the result of a conversation between the GP and patient about the various risks and benefits.

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Most statin side-effects not caused by the drugs, study finds

Almost all side-effects listed for statins are not caused by the drugs, according to the world’s most comprehensive review of evidence.Other than the well-known risks around muscle pain and diabetes, only four of 66 other statin side-effects listed on labels – liver test changes, minor liver abnormalities, urine changes and tissue swelling – are supported by evidence. And the risks are very small, according to the systematic review and meta-analysis published in the Lancet.Statins have been used by hundreds of millions of people worldwide over the last three decades and are proven to reduce heart attacks, strokes and cardiovascular deaths. At the same time, millions have been put off the drugs amid long-running safety concerns, with statin labels listing dozens of possible side-effects

2 days ago
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Alton Towers to test excluding people with autism and ADHD from disability fast lane

People with attention deficit hyperactivity disorder (ADHD), anxiety and autism will be prevented from using fast-lane disability queueing passes at Alton Towers during a trial over the February half-term holidays.Merlin Entertainments, which runs the theme park in Staffordshire, provides a “ride access pass” to visitors who have difficulty queueing due to a disability or medical condition.The pass allows guests to book a slot on a virtual queueing system for themselves and up to three companions. They are then allowed to wait for their turn away from often crowded queues.But the company said disabled visitors with “additional accessibility needs” have said the digital pass “simply isn’t working for them, particularly as demand has grown and queue times for these guests have increased”

2 days ago
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We need new drugs for mental ill-health | Letter

It is not only veterans and emergency workers living with post-traumatic stress disorder who could benefit if ministers heed the call from Sir Nick Carter (Ex-British army chief calls on ministers to back MDMA-assisted therapy for veterans, 1 February). Thousands of people who have major mental illness, and those dealing with bereavement and trauma, could be helped too.The shocking lack of progress in developing transformative psychiatric medicines, and a dearth of innovation has left clinicians with few weapons in their armoury to relieve mental pain. Families and people scarred by long-term distress tell us they are desperate for new treatments and therapies.At the Prince of Wales International Centre for Sane Research, our research centre in Oxford, we host clinical trials researching the medical use of innovative interventions such as esketamine and cannabidiol for psychiatric ill-health

2 days ago
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Violence is part and parcel of how prisons function | Letter

Alex South’s article (Death on the inside: as a prison officer, I saw how the system perpetuates violence, 13 January) limits the scope of prison violence to individual acts by focusing on prisoner-on-prisoner homicides. But violence is part and parcel of how prisons function.Hundreds of people die in prison each year, the majority by suicide, medical neglect or drugs. Even if we focus on homicides, they reveal how violence operates at an institutional level. Last year, the inquest of Sundeep Ghuman exposed how it was multiple failures by the prison, not just the actions of his cellmate, that led to his unlawful killing

2 days ago
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Blanket rule on trans women in men’s prisons would deny their identity, says Scottish government

A blanket rule to house transgender women in men’s prisons, even when they pose no risk to others, would be a “fundamental denial” of their identity, the Scottish government has argued.Placing a trans inmate in a prison that does not align with their lived gender runs counter to the aims of rehabilitation, Gerry Moynihan KC said on Thursday as he set out Scottish ministers’ position that a blanket rule on where prisoners are housed could contravene obligations under the European convention on human rights.In its latest court battle with the SNP government, For Women Scotland is challenging guidance that says trans prisoners should be housed according to individual risk assessment, which the group argues is contrary to the supreme court’s ruling on women-only spaces.For Women Scotland brought the original challenge that resulted in last April’s landmark ruling that the definition of a woman in equalities law refers to biological sex.Arguing that the supreme court decision was “not a universal proposition” but only for the purposes of the Equality Act, Moynihan said: “Where a transgender prisoner does not pose an article 8 problem, does not threaten the rights of others – are we to have an absolute rule that says that they must be accommodated in a prison of their sex?“Why? The sole reason is that they are to be classified as a man

2 days ago
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Does getting cold increase your chances of catching flu?

“Put your coat on or you’ll catch your death of cold.” It’s a common refrain that feeds the narrative that getting cold will make us sick. And it’s true that illnesses are more common during the winter months, but is it true that you are more likely to catch the flu if you forget your hat?Not exactly. Writing in The Conversation, medical microbiologist Manal Mohammed from the University of Westminster has explained that colds and flu are caused by viruses that spread either by respiratory droplets or person to person regardless of the temperature. However, there is a bit of truth in the idea – many viruses survive for longer in colder and dryer conditions, increasing the chances of them hanging around and infecting a fresh victim

3 days ago
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TikTok could be forced to change app’s ‘addictive design’ by European Commission

1 day ago
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Deepfake fraud taking place on an industrial scale, study finds

1 day ago
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Amazon reveals plans to spend $200bn in one year the day after Bezos guts Washington Post

2 days ago
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Bitcoin loses half its value in three months amid crypto crunch

2 days ago
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‘Orwellian’: Sainsbury’s staff using facial recognition tech eject innocent shopper

2 days ago
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How cryptocurrency’s second largest coin missed out on the industry’s boom

2 days ago