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GSK reports promising early results in ovarian and womb cancer drug trial

1 day ago
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GSK has revealed positive results for a treatment for gynaecological cancers as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company said that in an early-stage trial Mocertatug Rezetecan, known as Mo-Rez, shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.Based in London, GSK has recently gained plaudits for its work on tackling superbugs, becoming one of just three big pharma companies globally that continue to invest in anti-microbial research.However, commercially GSK has been eclipsed in recent years by its bigger British rival AstraZeneca, which last year outstripped GSK’s near-£33bn turnover by more than £10bn and whose market value is more than twice as high.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year.

Only a few patients needed to stop treatment because of side-effects, the most common being nausea,It is administered every three weeks via intravenous infusion,Combined with data from a separate, intermediate trial in China, these results give the British drugmaker the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK,Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates,With Mo-Rez we now have compelling evidence of a promising clinical profile.

”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year.Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Speaking to journalists before the conference, Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio.It is expected to be a blockbuster drug, with peak annual sales of more than £2bn, which GSK hopes will help it to achieve its 2031 sales target of £40bn.

Miels, an Australian who was brought in by his predecessor, Emma Walmsley, from AstraZeneca in 2017 and worked for Roche and Sanofi-Aventis, has announced several deals since taking the helm at GSK on 1 January, and vowed to show “scientific courage”.Abdullah said Miels, with whom he previously worked at AstraZeneca, had stepped up the pace of drug development.“The entire organisation is certainly really enjoying following this pace, the agility, and having the scientific courage.“His leadership style, the engagement, the strategic insight, the drug development expertise … you’re also seeing some of that come to life through the development programmes.”It has been less than a decade since GSK moved back into oncology under Walmsley, after GSK sold its cancer portfolio to Novartis in 2015 in a swap for the Swiss company’s vaccines business.

A few years ago GSK did not have any cancer drugs on the market but it now has four approved medicines and 13 in clinical development.Last year, oncology generated nearly £2bn in sales, up 43% from 2024, with sales of its endometrial cancer drug Jemperli soaring 89%.
politicsSee all
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What is the new EU bill and could it give UK ministers Henry VIII-type powers?

Ministers in Britain are planning a new bill that would bring into force a food and drink trade deal with the EU but also contain powers enabling the government to “dynamically align” with Europe. It would allow the UK to quickly implement evolving single market rules if it determines it is in the national interest, without having to face full parliamentary scrutiny.Keir Starmer has made it clear he wants the UK to go much further in terms of the economic relationship with the EU.A summit is planned for early summer with Brussels, which Starmer has stated he hopes will go further than the deal struck last year at Lancaster House that covered food and drink imports, as well as plans for emissions trading and electricity.To implement the food and drink deal, the government will introduce a bill with a so-called “dynamic alignment mechanism” that will allow the government to align UK standards as the EU evolves its own rules

about 15 hours ago
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UK will not join any Trump blockade of strait of Hormuz

The UK will not be involved in any blockade of the strait of Hormuz, the Guardian understands, after claims by Donald Trump on Sunday that the US would be blockading the waterway with the assistance of Nato allies.Speaking to Fox News, Trump said “it won’t take long to clean out the strait” and claimed “numerous countries are going to be helping us”, adding that the UK and other nations were sending minesweepers.The UK has previously suggested it could play a role in making the strait of Hormuz safe to pass, and it has mine-hunting systems and anti-drone capabilities already in the region.But there have been concerns in Whitehall that complying with Trump’s demand to send ships could escalate the crisis. The UK’s willingness to consider a role in mine-removal operations is seen as distinct from Trump’s blockade proposal

1 day ago
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Britain could adopt single market rules without MPs’ vote as part of UK-EU reset

Ministers are planning to fundamentally reshape Britain’s relationship with the European Union, with new legislation that could result in the UK signing up to EU single market rules without a normal parliamentary vote.In a major development in the prime minister’s push for closer ties with the continent after the Iran war, the Guardian understands ministers are bracing to face down opposition to “dynamic alignment” with the EU from those who “scream treason” over the powers in a new EU-UK reset bill.After weeks of Donald Trump’s war with Iran that have exposed the fragility of the UK’s damaged special relationship with the US, ministers argue the move will add billions to the UK economy, help temper the cost of the conflict and boost sluggish productivity.A new bill, which will bring into force the food and drink trade deal with the EU, will contain powers enabling the government to dynamically align with Europe on areas where it has already made agreements. But it will also allow the UK to quickly implement evolving single market rules if it determines it is in the national interest, without having to face full parliamentary scrutiny each time

1 day ago
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Reform UK’s ugly response to slavery reparations claims | Letters

It is not necessary to agree with the slavery reparations movement in order to see through the crude and threadbare logic of Zia Yusuf’s tirade against it (Reform UK would stop visas for people from countries seeking slavery reparations, 7 April). Britain’s prominent role in ending the slave trade and subsequently slavery neither absolves its involvement in those enterprises nor erases their effects. Endless reiteration of it does, however, encourage a sentimental attachment to a single, insular version of history.Similarly, to claim that advocates for reparations are using history “as a weapon to drain our treasury” is a wilful misrepresentation, designed to jolt the indignant reflexes of Reform UK supporters too lazy to engage with extensive argument.But the ugly coup de grace in Yusuf’s diatribe is his willingness to demonise whole populations whose governments have the audacity to question historical narrative or to possess opinions built on principle – a crime so heinous that it deserves the denial of visas for entry to Britain

1 day ago
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Sorry, Keir Starmer, but pensioners don’t feel better off under this government | Letter

For the most part in his recent article (Workers, pensioners and children: all better off. Ignore the critics – we really are standing up for working people, 5 April), Keir Starmer rightly flags up the introduction of policies supporting the less well off in this society. However, I believe it was an ill-considered move to include the statement about increasing the state pension. As a pensioner I am not seeing a straightforward improvement and instead seeing a policy that is reducing the benefit of those increases.The triple lock, established by a Conservative–Liberal Democrat government in 2010, was designed to ensure that pensioners who had made tax and national insurance contributions throughout their working lives did not see their pension watered down

1 day ago
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Votes for populist parties in May elections will put NHS at risk, Streeting says

Voters in May’s local and devolved elections risk putting the NHS in jeopardy if they vote for populist parties, Wes Streeting has said, as he sought to make the health service a key battleground.“The founding principles of the NHS are at greater threat than at any time since the NHS was founded in 1948,” the health secretary said.He warned that there was “a particular jeopardy” for the NHS in Wales, where Labour faces electoral wipeout at the hands of Reform UK and Plaid Cymru, with the latter pitching itself to voters as the best “stop Reform” option.Streeting called Labour’s progressive rivals “rookies” and said he “refuse[d] to believe that many people in Wales would vote for Reform if they knew where Nigel Farage stood on the NHS”.Streeting argued that the NHS in Scotland was weaker after almost two decades of SNP governance, while in England Labour-run councils would work more efficiently with Labour in government

1 day ago
trendingSee all
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Goldman Sachs chief ‘hyper-aware’ of risks from Anthropic’s Mythos AI

about 10 hours ago
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Oil price tops $100 a barrel as US blockades strait of Hormuz; Goldman Sachs posts rise in profits – as it happened

about 11 hours ago
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Elon Musk’s X cuts payments to users who post clickbait

about 15 hours ago
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Booking.com warns customers of hack that exposed their data

about 16 hours ago
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Rory McIlroy says preparation at ‘home course’ Augusta aided Masters defence

about 7 hours ago
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County cricket: Anderson stars as Lancashire win thriller against Derbyshire – as it happened

about 9 hours ago