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Big pharma firms have paused nearly £2bn in UK investments this year

about 7 hours ago
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Big pharmaceutical companies have ditched or paused nearly £2bn in planned UK investments so far this year, causing “suffering” to patients, as ministers gear up for discussions with Donald Trump amid a row over drug pricing,The government’s plan for the life science sector, a key pillar of the economy, has been thrown into disarray, after US drugmaker MSD’s shock announcement last Wednesday that it would scrap its £1bn London research centre,Two days later, AstraZeneca decided to halt a planned £200m expansion of its research facilities in Cambridge,Combined with a scrapped project by AstraZeneca in Liverpool and a shelved Eli Lilly lab in London, four projects worth more than £1,7bn have been pulled or paused this year.

In total, decisions over 13 major projects or companies have damaged the UK’s pharma industry since 2022, also including site closures and stock market delistings.Pharma companies have accused the government of not spending enough on new medicines, arguing that there is little incentive for them to develop drugs and test them in a country that does not value innovation sufficiently.More recriminations are expected when MPs on the science, innovation and technology committee question MSD’s UK and Ireland managing director, Ben Lucas, about its decision on Tuesday afternoon.He will appear alongside AstraZeneca UK president Tom Keith-Roach, Association of the British Pharmaceutical Industry chief executive Richard Torbett and representatives of the government, including the science minister Lord Vallance, a former GSK executive.The US ambassador to the UK, Warren Stephens, asked the chancellor, Rachel Reeves, to offer drug companies a better deal on pricing when the two met at a private dinner in London recently, the Financial Times reported.

The intervention came before Trump’s visit to the UK this week.The US president has criticised foreign nations for “freeloading on US innovation”.Drug prices are much higher in the US and companies have been accused of “price gouging” in the past.Meanwhile, Guy Oliver, the UK head of the US drugmaker Bristol Myers Squibb, told the Times that, because of “chronic underinvestment” in medicines, the US drugmaker had cancelled 34 partnerships with the NHS in the past year.“There is a human cost to all of this.

Patients are really suffering, and have been suffering for many, many years now,” he said.Drugmakers have become more vocal over the UK’s shortcomings since months-long negotiations over drug pricing broke down in late August, when the health secretary, Wes Streeting, gave companies an ultimatum over his latest “generous” offer – but was rejected.This means that the voluntary scheme for branded medicines pricing, access and growth, under which pharma companies pay back a chunk of their UK revenues to the NHS, continues at a rate the industry says is “unsustainable”.The minimum clawback rate of 23.5% for newer medicines is much higher than payment rates in other European countries.

MSD, known as Merck in the US, said it would discontinue all research and development activities in the UK, which means 125 scientists based at the Francis Crick Institute and the London BioScience Innovation Centre will lose their jobs.Also last week, the US drugmaker Eli Lilly said its planned London Gateway Lab, part of a £279m investment, was on hold, “as we are awaiting more clarity around the UK life sciences environment”.Britain’s biggest drugmaker, AstraZeneca, which was at the forefront of the government’s efforts to make Covid vaccines available during the pandemic, already pulled the plug on the £450m expansion of its vaccine site in Speke in Liverpool in February after failing to agree a state support package.The French pharma group Sanofi’s UK head of market access, Paul Naish, has said substantial investment is now on hold.“This is an intolerable situation for too many [patients] in this country and that is why government needs to work with the sector,” he said.

The Swiss drugmaker Novartis is also holding off future investments in UK manufacturing or research, it is understood.Over the past 16 years, it has scaled back its UK operations from seven sites and more than 4,000 employees to one site in London housing 1,200 staff.Meanwhile, Germany’s BioNTech said its £1bn, 10-year partnership with the UK government, aimed at speeding up trials of its cancer medications, remained on track.Several hundred patients have been treated with experimental cancer immunotherapies through the collaboration, and new research centres are planned in London and Cambridge.The US biotech Moderna, known for its Covid vaccine, opened a new vaccine manufacturing site in Harwell, Oxfordshire in May.

Sign up to Business TodayGet set for the working day – we'll point you to all the business news and analysis you need every morningafter newsletter promotionSeptember AstraZeneca pauses £200m research lab in Cambridge (1,000 jobs)September Merck scraps £1bn London research centre (125 jobs)September Eli Lilly pauses London Gateway lab, part of £279m investment2025-26 Haleon closing Maidenhead site (435 jobs)July Indivior: based in Slough, delisted from London Stock Exchange (LSE)July Verona Pharma: based in London, sold to MSD after delisting from LSE in 2020July Adaptimmune Therapeutics sells four cell therapy assets to US WorldMeds and cuts UK workforce by 62%June GSK shuts Ulverston factory (100 jobs) and makes cuts at Barnard Castle in October (200 jobs)February AstraZeneca scraps £450m investment in Speke, LiverpoolJanuary Rentschler Biopharma closes Stevenage site (30 jobs)2024 Sanofi reduced its Kymab labs in Cambridge (50 jobs)2023 Recipharm closes Queenborough site on Isle of Sheppey (150 jobs)2022 Novartis sells Grimsby site (200+ jobs)
foodSee all
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Tillingham, Peasmarsh, East Sussex: ‘Not much cooking was going on’ – restaurant review

The restaurant of this farm in breathtakingly beautiful countryside is missing its potentialTillingham is essentially a natural biodynamic wine production business working over 70 acres of gently rolling countryside, near Rye and the Romney Marshes in East Sussex. If only their main trouble was making bottles of chardonnay and pinot blanc, or selling pretty Tillingham tea towels at £36 a pop. But no, Tillingham has (quite literally) many other plates to juggle: it has a fancy restaurant and a vast barn from which they serve pizza, too.There’s also the option to stay over in bell tents, no less, if posh hen weekends or corporate bonding sessions are required. Or in bricks-and-mortar rooms with actual plumbing, if the tent’s compost toilet is not for you

2 days ago
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Vegan burgers are losing the US culture war over meat: ‘It’s not our moment’

Plant-based burgers were supposed to help wean Americans off their environmentally ruinous appetite for meat. But sales have plummeted amid a surging pro-meat trend embraced by the Trump administration, raising a key question – will vegetarianism ever take hold in the US?This year has been a punishing one for the plant-based meat sector, led by companies such as Beyond Meat and Impossible Foods, with sales of refrigerated products slumping 17%. This follows a difficult 2024, during which sales fell 7%, furthering a multi-year spiral – last year Americans purchased 75m fewer units of plant-based meat than they did in 2022.Despite hopes that burgers, sausages and chicken made from soy, peas and beans would curb Americans’ love of eating butchered animals – thereby reducing the rampant deforestation, water pollution and planet-heating emissions involved in raising livestock – these alternatives languish at just 1% of the total meat market in the US.Instead, a resurgent focus on meat has swept the US, pushed by industry lobbyists and online wellness influencers who advocate greater protein consumption via the carnivore diet and deride plant alternatives as overly processed

4 days ago
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Helen Goh’s recipe for plum and star anise frangipane tart | The sweet spot

Late-season plums are wonderful to bake with; juicy and slightly astringent as you get closer to the skin, they soften into a rich, almost winey sweetness. And, when they’re nestled into soft almond cream and scented with star anise, they make a delicious tart for any time of day. Serve warm with pouring cream as pudding or cold with a cup of tea.Prep 15 minChill 1 hr 30 min Cook 1 hr 45 min Serves 8-10For the pastry 300g plain flour, plus extra for dusting 90g icing sugar ¼ tsp salt 200g cold unsalted butter, cut into cubes, plus an extra 10g, melted, for greasingFinely grated zest of 1 lemon 1 large egg yolk 20ml ice-cold waterFor the plums 4-5 medium plums (about 100g each), halved, stoned and sliced into 1cm-wide wedges1 tbsp caster sugar 3 whole star anise (about 3g), finely ground in a mortar to get 1½ tspFor the filling125g unsalted butter, at room temperature125g caster sugar Finely grated zest of 1 orange¼ tsp fine sea salt ½ tsp almond extract, or vanilla extract 2 eggs, at room temperature40g plain flour 125g ground almonds Icing sugar, to finishTo make the pastry, put the flour, icing sugar and salt in a food processor and pulse a few times to combine and aerate. Add the butter and lemon zest, then process to the consistency of fresh breadcrumbs

4 days ago
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Why Portuguese red blends fly off the shelves | Hannah Crosbie on drinks

It has come to my attention that I haven’t written a column dedicated to red wine in almost two months. So sue me – it’s been hot. Mercifully, though, temperatures look to be dropping soon, so we can once again cup the bowl of a wine glass without worrying about it getting a little warmer as its aromas unfasten.The Guardian’s journalism is independent. We will earn a commission if you buy something through an affiliate link

5 days ago
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Rachel Roddy’s recipe for fish baked with tomatoes, olives and capers | A kitchen in Rome

Al cartoccio is the Italian form of en papillote, meaning “contained” or “in paper”, which is an effective cooking method that traps the moisture (and flavour) released from the ingredients and creates a steamy poaching chamber – it’s a bit like a Turkish bath for food! Once out of the oven, but still sealed, the scented steam trapped in the paper returns to liquid and creates a brothy sauce. Fish with firm white or pink flesh that breaks into fat flakes is particularly well suited to cooking al cartoccio, both whole fish (cleaned and on the bone) and individual filets (estimate 110g-140g per person).When choosing fish, keep in mind our collective default to cod and haddock, both members of the so-called “big five” that make up a staggering 80% of UK consumption. Instead, look out for other species, such as hake, huss or North Sea plaice, ASC-certified Scottish salmon, sea trout or farmed rainbow trout. For more detailed and updated advice, the Marine Conservation Society produces an invaluable, area-by-area good fish guide that uses a five-tiered system to rank both “best choice” and “fish to avoid” based on the species, location and fishing method

5 days ago
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How to turn a single egg and rescued berries into a classic British dessert

Just a single egg white can be transformed into enough elegant meringue shards to crown more than four servings of pudding, as I discovered when, earlier this year, I was invited by Cole & Mason to come up with a recipe to mark London History Day and decided to do so by celebrating the opening of the Shard in 2012. Meringue shards make a lovely finishing touch to all kinds of desserts, from a rich trifle to an avant-garde pavlova or that timeless classic, the Eton mess. As for the leftover yolk, I have several recipes, including spaghetti carbonara (also featuring salt-cured egg yolks that make a wonderful alternative to parmesan) and brown banana curd.Architect Renzo Piano is said to have sketched his original idea for the Shard on the back of a restaurant napkin. Similarly, whenever I design a more conceptual dish such as this one, I love to start by drawing it in my sketchbook, to develop an idea of what the dish will look like, and while I was drawing the angular lines of the Shard, it reminded me of a minimalist dessert I’d eaten at the seminal AT restaurant in Paris that featured grey meringue shards that seemed to me to perfectly emulate the dramatic geometry of that iconic London building

6 days ago
politicsSee all
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Who were the key figures at the ‘unite the kingdom’ rally in London?

about 16 hours ago
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Police search for 11 violent disorder suspects after ‘unite the kingdom’ march

about 17 hours ago
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Starmer aide’s exit over lewd Abbott jokes deepens crisis as Trump arrives

about 17 hours ago
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UK government ‘disappointed’ charges dropped against men accused of spying for China

about 18 hours ago
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Danny Kruger takes Reform back to full strength – so who’ll be next to quit? | John Crace

about 19 hours ago
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MP Danny Kruger says Tory party ‘is over’ as he defects to Reform

about 19 hours ago