We need new drugs for mental ill-health | Letter
It is not only veterans and emergency workers living with post-traumatic stress disorder who could benefit if ministers heed the call from Sir Nick Carter (Ex-British army chief calls on ministers to back MDMA-assisted therapy for veterans, 1 February).Thousands of people who have major mental illness, and those dealing with bereavement and trauma, could be helped too.The shocking lack of progress in developing transformative psychiatric medicines, and a dearth of innovation has left clinicians with few weapons in their armoury to relieve mental pain.Families and people scarred by long-term distress tell us they are desperate for new treatments and therapies.At the Prince of Wales International Centre for Sane Research, our research centre in Oxford, we host clinical trials researching the medical use of innovative interventions such as esketamine and cannabidiol for psychiatric ill-health.
The government must prioritise research into alternative and more effective treatments, rather than relying on drugs invented and first made available over 60 years ago.Marjorie WallaceChief executive, Sane Have an opinion on anything you’ve read in the Guardian today? Please email us your letter and it will be considered for publication in our letters section.
Amazon reveals plans to spend $200bn in one year the day after Bezos guts Washington Post
Amazon announced plans to spend $200bn on artificial intelligence and robotics this year, the latest tech giant to vow fresh enormous investments in the artificial intelligence arms race.The news of the investment comes one day after the Washington Post, owned by Amazon founder Jeff Bezos, announced it was cutting approximately a third of employees.Amazon also reported $213bn in revenue on Thursday. The fourth-quarter earnings of the e-commerce and cloud-computing giant came in slightly below Wall Street estimates even as sales and growth surged.Amazon will increase capital spending to $200bn this year from $125bn, CEO Andy Jassy said in a press release
Bitcoin loses half its value in three months amid crypto crunch
Bitcoin’s price sank to $63,000 on Thursday, its lowest level in more than a year, and half its all-time peak of $126,000, reached in October 2025. A months-long dip in cryptocurrency prices has tanked shares of companies that have increasingly invested in bitcoin, exacerbating broader stock market jitters.Bitcoin rode a high during Donald Trump’s ascent to the presidency in 2024 and throughout 2025; its price steadily increased as the president made one industry-friendly move after another. Crypto’s largest currency hit $100,000 for the first time in December 2024 and even rose to a record high of $126,210.50 on 6 October, according to Coinbase
‘Orwellian’: Sainsbury’s staff using facial recognition tech eject innocent shopper
A man was ordered to leave a supermarket in London after staff misidentified him using controversial new facial recognition technology.Warren Rajah was told to abandon his shopping and leave the local store he has been using for a number of years after an “Orwellian” error in a Sainsbury’s in Elephant and Castle, London.He said supermarket staff were unable to explain why he was being told to leave, and would only direct him to a QR code leading to the website of the firm Facewatch, which the retailer has hired to run facial recognition in some of its stores. He said when he contacted Facewatch, he was told to send in a picture of himself and a photograph of his passport before the firm confirmed it had no record of him on its database.“One of the reasons I was angry was because I shouldn’t have to prove I am innocent,” Rajah said
How cryptocurrency’s second largest coin missed out on the industry’s boom
US crypto developer Danny Ryan submitted a proposal in November 2024 to Vitalik Buterin, the founder and symbolic leader of Ethereum, a prominent blockchain powering the world’s second-largest cryptocurrency. Ryan, who had worked for seven years at the Ethereum Foundation (EF), Ethereum’s de facto governing body, suggested that Ethereum could be on the cusp of an era-defining shift.Since its founding in 2014, the foundation had prioritized technical upgrades and had avoided centralizing power while its user base was growing, but Ethereum had now grown up, and the cryptocurrency world around it had grown up, too. The EF could now “exercise a stronger voice” without compromising its ethos of decentralization, Ryan said – and he was open to leading that charge if appointed as the foundation’s new executive director.Ryan told the Guardian that he could see how political tides were changing “overnight”, which informed his proposal
What does the disappearance of a $100bn deal mean for the AI economy?
Did the circular AI economy just wobble? Last week it was reported that a much-discussed $100bn deal – announced last September – between Nvidia and OpenAI might not be happening at all.This was a circular arrangement through which the chipmaker would supply the ChatGPT developer with huge sums of money that would largely go towards the purchase of its own chips.It is this type of deal that has alarmed some market watchers, who detect a whiff of the 1999-2000 dotcom bubble in these transactions.Now it seems that Nvidia was not as solid on this investment as had been widely believed, according to the Wall Street Journal. Negotiations had not progressed, with Jensen Huang, Nvidia’s chief executive, privately emphasising that the deal was “non-binding” and “not finalised”
Google Pixel Buds 2a review: great Bluetooth earbuds at a good price
Google’s latest budget Pixel earbuds are smaller, lighter, more comfortable and have noise cancelling, plus a case that allows you to replace the battery at home.The Guardian’s journalism is independent. We will earn a commission if you buy something through an affiliate link. Learn more.The Pixel Buds 2a uses the design of the excellent Pixel Buds Pro 2 with a few high-end features at a more palatable £109 (€129/$129/A$239) price, undercutting rivals in the process
Bald eagles and Lynyrd Skynyrd: is Budweiser’s all-American Super Bowl ad serious?
Barclays reportedly cuts ties with lobbying firm co-founded by Peter Mandelson
Shell will consider fossil fuel investment in Venezuela, says chief executive
Rio Tinto and Glencore abandon revived $260bn merger plan
US job openings dropped to a five-year low in December 2025, report shows
Bank of England holds interest rates and ‘shocked’ over Mandelson; Rio-Glencore merger talks collapse – as it happened