Repurposed drug may extend survival in aggressive ovarian cancer, trial shows

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A drug originally used to treat a rare disease could extend the lives of patients with an aggressive form of ovarian cancer, according to a clinical trial.Platinum-resistant ovarian cancer occurs when the disease progresses within six months of starting platinum-based chemotherapy.This form of chemotherapy is different from other types because it uses compounds that contain platinum to destroy cancer cells by preventing them from dividing.On average, patients with ovarian cancer that is resistant to this type of chemotherapy are typically expected to survive for only a year after diagnosis, and their treatment options are limited.A study published in the Lancet analysed data from 381 patients with platinum-resistant ovarian cancer.

Participants received either usual treatment or relacorilant, a pill used to treat Cushing’s syndrome, a condition caused by excessive levels of the hormone cortisol.After an average follow-up of two years, the results showed a 35% reduction in the risk of death among patients treated with relacorilant compared with those receiving usual care.On average, patients in the relacorilant group lived four months longer than those in the control group.The researchers concluded that these findings supported relacorilant as a potential new standard treatment option for patients with platinum-resistant ovarian cancer.A separate study involving 643 platinum-resistant ovarian cancer patients found those treated with pembrolizumab alongside usual care lived for an average of 17.

7 months, while those who had usual care alone survived for an average of 14 months.Pembrolizumab is an immunotherapy drug that works by stimulating the immune system to attack cancer cells.Ovarian cancer is the sixth most common cancer among women in the UK, with about 7,600 cases diagnosed each year.It accounts for about 4% of all new cancer cases among women, and there are about 3,900 deaths annually.Both trials are at phase 3 and require further testing before they can be approved in the UK.

However, relacorilant and pembrolizumab have been approved in the US by the Food and Drug Administration for the treatment of platinum-resistant ovarian cancer,
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Jimmy Kimmel on Trump’s Iran threats: ‘The most dangerous episode of the Celebrity Apprentice yet’

Late-night hosts reacted to a late-stage ceasefire with Iran, after Donald Trump promised “a whole civilization will die tonight” in an extremely alarming post.Tuesday was just “another crazy day here in the United States of America!” said Jimmy Kimmel, after the president promised, then called off, destructive attacks in Iran by 8pm that evening. “Probably the most dangerous episode of the Celebrity Apprentice yet. Today was D-Day – in this case, the D stands for dementia, but it was D-Day.”“We’re coming to you from Los Angeles for the local time’s just after 5pm, which was Trump’s deadline for Iran to ‘Open the F-ing strait or you’ll be living in hell,’” the host explained

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Eminem’s 8 Mile helped me survive abuse – and opened my eyes to a world outside of orthodox Judaism

My upbringing denied me access to the arts and led to me bottling up my feelings about what was happening to me. Then I saw Eminem taking control of his destiny, and decided I needed to do the sameAt 15, I had never been to the cinema, or even watched a movie. I grew up in a strictly Orthodox Charedi Jewish household, the daughter of a rabbi, in Glasgow, where we had next to no exposure to cultural influences beyond our religious world. The bookshelves were stacked with biblical texts and teachings, we sang in Yiddish and I only saw TV at my less religious grandparents’ house, where we could watch the end of the tennis if it was finishing as we arrived.By my mid-teens, my parents had moved to Jerusalem and sent me to live in Manchester, with a scholar who would later abuse me

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From The Drama to Malcolm in the Middle: your complete entertainment guide to the week ahead

R-Patz and Zandaya star in a romcom with bite, and the lovably dysfunctional family is back in a revival of the turn-of-the-millennium comedy hitThe DramaOut now It is hard to imagine a more zeitgeist-flavoured proposition than Zendaya and Robert Pattinson starring in a dark romantic comedy from A24 – and frankly we are here for it. The pair play a couple whose relationship is tested by the revelation of brand new information during their engagement. Directed by Kristoffer Borgli (Dream Scenario).Kim Novak’s VertigoOut now The notional star of Alfred Hitchcock’s masterly ode to obsession is James Stewart, but it is the image of Kim Novak in her iconic dual role that endures. Documentarian Alexandre O Philippe sits down with the actor as she discusses her career in general and her iconic work on Vertigo in particular

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‘After one gig, someone stole my car with my dole money in it’: Morcheeba on how they made The Sea

We’d made our first album and were waiting for it to come out. But we wanted to carry on writing more stuff while we were in the mood. I even cut Christmas dinner short at my uncle’s in Brixton, London, so we could get back to the studio. We would work until we passed out, then I’d sleep underneath the mixing desk with my head in the bass drum, as that’s where the pillow was.One night in early 1996, my brother Paul and I stayed up all night drinking vodka, trying to write as many songs as we could, and we came up with much of the Big Calm album

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Jimmy Kimmel on Mike Johnson’s new award for Trump: ‘You can almost feel his spine exiting his body’

Late-night hosts mocked the Republican party’s inaugural “America First” award for Donald Trump as he finally reveals the “present” he received from Iran.Jimmy Kimmel had a field day with the Republican National Committee’s inaugural “America First” award, presented to Trump on Wednesday by Mike Johnson, the House speaker, who described the prize as “appropriate for the new golden era in America”.“I can’t figure out who should be more embarrassed: the guy who came up with the new award, or the guy who proudly accepted the new award,” Kimmel laughed.“Watch Mike Johnson here,” he added before a clip of the lawmaker’s speech. “You can almost feel his spine exiting his body

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Kimmel on Trump: ‘He talks about war like he’s bragging about women with Billy Bush’

Jimmy Kimmel expressed frustration over Donald Trump’s confusing statements on Iran while also expressing shock over Melania Trump’s surprise statement.The ABC host spoke about the ongoing war in Iran that is happening “for reasons known only to Donald Trump” and how we remain unsure over the strait of Hormuz and whether it is or isn’t open.Kimmel joked that with all the back and forth over it, “basically after all this he got us is constipation”.Trump has been teasing a “grand reopening” as well as a possible business partnership with Iran “which makes no sense”.Kimmel joked that “he’ll put it on his vision board and will it to be true” before moving on to his threats on social media teasing the military’s “next conquest”