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Prostate cancer drug that can halve death risk to be offered to thousands in England

2 days ago
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Thousands of men with advanced prostate cancer in England are to be offered a drug that can halve the risk of death,In guidance published on Friday, the National Institute for Health and Care Excellence (Nice) gave the green light to darolutamide, which attacks the disease by starving cancer cells and has fewer side-effects than existing treatments,At least 6,000 men a year with metastatic hormone-sensitive prostate cancer will get access to the novel treatment, also known as Nubeqa and made by Bayer, on the NHS,Darolutamide, taken as two tablets twice daily, works by blocking hormones fuelling cancer growth,The treatment is delivered alongside androgen deprivation therapy (ADT), a hormone therapy that lowers testosterone levels.

Data show the treatment combination is better than using ADT alone and is as effective as other combination treatments, according to Nice.Helen Knight, the director of medicines evaluation at Nice, said: “I’m pleased we can recommend this new combination treatment, which provides another much-needed option for people with metastatic hormone-sensitive prostate cancer.“We are determined to ensure that effective treatments such as darolutamide, which can help extend the length and quality of people’s lives, are made available fast to the people who need them.”For those with metastatic hormone-sensitive prostate cancer – where the disease has spread to other parts of the body – treatment options typically involve ADT, either on its own or combined with other drugs.Trials show adding darolutamide to standard ADT cuts the risk of death by 46% compared with ADT alone, with evidence suggesting it is as effective as other combination treatments already recommended by Nice and available on the NHS.

The charity Prostate Cancer UK said the new drug offered men a “gentler” treatment option with fewer side-effects compared with ADT in combination with other therapies.This could benefit older men or those who cannot be prescribed current treatments.Amy Rylance, an assistant director of health improvement at Prostate Cancer UK, said: “Darolutamide is an important new treatment that gives thousands of men with incurable prostate cancer another effective option that could halve their risk of death.“While it’s just as effective as existing drugs, it has fewer side-effects.Our hope is that this will make it easier for more men to benefit from these treatments – because right now, too many men are missing out on the treatments that can extend their lives.

“It’s great that new drugs like this are being approved but this is only the first step – that’s why the government must ensure the new national cancer plan includes steps to make sure the right treatments reach the men who need them.”Rylance said she had concerns that some men now eligible for the drug may still be unable to access it because of a “postcode lottery of care” in England.She highlighted data from the recent national prostate cancer audit, which showed that less than half (47%) of men with advanced prostate cancer got the latest recommended treatments.Peter Johnson, the clinical director for cancer at NHS England, said: “This decision provides another welcome treatment option for patients living with an advanced and aggressive form of prostate cancer.“With several proven therapies already available on the NHS, this approval gives clinicians and their patients more flexibility to choose the approach best suited to individual circumstances and clinical needs.

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Timely assurance from Lear’s Kent | Letters

The passing of John Woodvine (Obituary, 13 October) reminded me of the time when four of us University of East Anglia students went to the Norwich Theatre Royal to see the Actors’ Company touring King Lear in June 1974.We were early and went for a something to eat at a newly opened “burger” style restaurant with booths and partitions so you couldn’t see who was at adjacent tables – a novelty at the time. The service was very slow and we were concerned that we would be late for the theatre.Suddenly a head appeared over the partition and said: “Don’t worry – they won’t start without me!” It was John Woodvine, who turned out to be the Earl of Kent and was the first to speak in the play. Needless to say we made it in time

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The Guide #214: Sleep-inducing songs and tranquilising TV – the culture that sends us to sleep (in a good way)

How do you sleep at night? If you’re like Hannah, a recent subject of the Guardian’s My cultural awakening column, it’s to the sound of a rat whisking eggs. The series shares stories of people who made a significant life change thanks to a piece of popular culture, and in the case of Hannah, that meant curing insomnia by watching Ratatouille. Every night for the last 15 years, at home or abroad, she switches on the Pixar classic and, within minutes, finds herself dropping off, thanks to the film’s comforting, consistent soundscape. It’s so effective, in fact, she’s never even seen it all the way through.Hannah’s might be a bit of an extreme example, but her tale does touch on something universal: culture seems to play an increasingly important role these days in helping people nod off

1 day ago
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Seth Meyers on Trump’s White House ballroom: ‘This couldn’t be any more of a bait and switch’

Late-night hosts mocked Donald Trump’s demolition of the East Wing of the White House and the corporate sponsors of his $300m gilded ballroom.On Thursday’s Late Night, Seth Meyers expressed disbelief over the president’s gilded ballroom project for the White House. “It would be bad enough if Trump’s biggest priority was just building a gilded vanity project for himself, but it’s so much worse,” he said. “Because to do it, he’s tearing down a somewhat well-known and beloved piece of property.”That would be the entire East Wing of the presidential residence, which has stood for 120 years

1 day ago
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Seth Meyers on Trump’s White House demolition: ‘This is insane’

Late-night hosts dissected Donald Trump’s kingly behavior, from the destruction of the White House’s East Wing to his demand for payment from the justice department.“We have warned for years that Donald Trump is destroying American institutions,” said Seth Meyers on Wednesday evening, “but of course when we said ‘destroying’, we meant metaphorically speaking. We didn’t mean that he was literally destroying buildings.”“But I guess Trump heard that and thought, ‘On it.’ Because now he’s literally destroying the East Wing of the White House,” the Late Night host continued

2 days ago
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Toe-curling fashion: how did toe shoes become so popular?

Caitlin, I am a big proponent of not yucking someone else’s yum. But this is testing me. What are on those girlies’ feet?They’re toes, Cait. They’re toes. More specifically, toes encased in rubber to create a kind of foot-glove-trainer

2 days ago
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Stephen Colbert on Trump’s White House East Wing demolition: ‘So deeply unsettling’

Late-night hosts reacted to Donald Trump’s partial demolition of the East Wing of the White House for his proposed $250m gilded ballroom.“At this point, we’re nine months into this, you’d think it would be impossible for us to be shocked by Donald Trump,” said Stephen Colbert on Tuesday’s Late Show. “But give the man credit – every so often, he takes the time to attach the electrodes to our nipples. And then it feels like the first time.”Case in point: on Monday, as part of his White House renovation project to construct a gilded ballroom, Trump sent out a backhoe to rip off a part of the East Wing

3 days ago
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Wall Street and FTSE 100 hit record highs after US inflation report fuels interest rate cut hopes – as it happened

1 day ago
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Nigel Farage seeks influence over Bank of England in same vein as Trump and US Federal Reserve

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NatWest boss warns against higher bank taxes as lender’s profits rise 30%

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Dash for gold helps drive retail sales in Great Britain to three-year high

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Car production slumps to a 73-year low after JLR cyber-attack

2 days ago
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Battle between Netherlands and China over chipmaker could disrupt car factories, companies say

2 days ago